Endocrine Abstracts

Differentiated thyroid carcinoma (DTC) is the most frequent endocrine neoplasm. Follicular thyroid carcinoma (FTC) is the second histological variant in frequency after papillary thyroid carcinoma (PTC). Cerebellar metastases from DTC are extremely rare, corresponding about 1% of all cerebellar metastases, and being the majority metastases from PTC. To the best of our knowledge there have been no reported cerebellar metastases from CFT so far. We present here the first clinica...

Background: IGF1 is mainly produced in the liver and it induces beneficial effects on many systems. However, the role of IGF1 on the liver itself is poorly understood, probably due to the fact that healthy hepatocytes barely express IGF1 receptors. Previous works in our group showed that IGF1 supplementation induces beneficial actions in cirrhosis, inducing a relevant histological improvement, reducing fibrosis1. Based on these data the aim of this work was to inqui...

Background: IGF1 is mainly produced in the liver and it induces beneficial effects on many systems. However, the role of IGF1 on the own liver is poorly understood, probably due to the fact that healthy hepatocytes barely express IGF1 receptors. Previous works in our group showed that IGF1 supplementation induces beneficial actions in cirrhosis, including antioxidant, anti-inflammatory and antifibrogenic effects. Based on these data the aim of this work was to deep into the me...

Multiple endocrine neoplasia type 2 (MEN2) is a hereditary condition with an autosomal dominant type of inheritance. It is evident that MEN2 is characterized by the presence of Medullary Thyroid Cancer (MTC) as a permanent symptom, the combination of which with pheochromocytoma and parathyroid syndrome is referred to as MEN-2A syndrome. The aim of our study was the creation of a database of patients with MTC and analysis of the data.Materials and methods...

The medical and social significance of the Multiple Endocrine Neoplasia type 2 (MEN2) is due to the severity of the manifestations of the disease components, namely the tumor process progression, a high risk of vascular accidents, pathological fractures of the femoral neck/spine, gastrointestinal bleeding, chronic renal failure. Late detection of pathology is associated with high mortality due to medullary thyroid cancer (MTC). Thus, the aim of the study was to establish the c...

The aim of this research was foot mineralization level definition by means of the two-absorbing X-ray densitometer and marking out group of the greater risk of a foot mineralization disorder development at patients with diabetes.Materials and methods: Decrease in a foot mineralization at diabetes patients conformed a mineralization of metatarsal bones below 0.50 g/cm2 level and (or) tarsal bones below 0.69 g/cm2 level.<p class="...

Objective: To assess the association between empty sella (ES) and primary autoimmune hypothyroidism, and the possibility of a common pathogenesis.Patients and methods: We retrospectively studied all patients with presumed ES diagnosed in the last 20 years, most of whom were treated and followed up by our Endocrinology Department. Subjects with a known aetiology were excluded. Incomplete records or those with a doubtful diagnosis were also excluded. A tot...

Introduction: Pituitary adenomas are the most common cause of sellar masses from the third decade on, accounting for up to 10 percent of all intracraneal neoplasms.Objective: To review pituitary adenomas diagnosed in Burgos.Patients and methods: It was a retrospective study in which we reviewed a total of 90 pituitary adenomas detected in Burgos from 1983 to our days.Results: About 65% were macroadenomas and ...

Introduction: Metabolic dysfunction-associated fatty liver disease (MAFLD) is present in a high percentage of obese patients undergoing bariatric surgery (BS), being an effective strategy for the remission of MAFLD. A significant proportion of patients still have steatohepatitis even after considerable weight loss and metabolic improvements. Liver biopsy remains the definitive test to classify a patient with steatohepatitis, but it is an invasive test. The use of non-invasive ...

Introduction: Vitamin D deficiency is a common health problem worldwide, particularly in elderly patients. Vitamin D is considered a key hormone in mineral and bone metabolism, as well as in functions such as the regulation of cell proliferation and differentiation, its immunoregulatory activity, its effect on the cardiovascular system and its neuroprotective and anti-ageing effects, among others. Hypovitaminosis D has been linked in multiple studies to a higher incidence and ...